Our vision is to provide a more complete understanding of the regulation and function of RNA processing in muscle development. Along the way, we are identifying which proteins can bind to and regulate RNA, working to gain a deeper understanding of muscle development itself and investigating the function of alternatively spliced isoforms during myogenesis.
Project 1: Doctoral candidate Elena Nikonova is investigating potential isoform-specific functions of the RNA binding protein Bruno1.
Project 2: Doctoral candidate Shao-Yen Kao is characterizing the phenotype of U2 spliceosome component Scaf6/CHERP in muscle.
Additional projects: We are identifying RNA binding proteins in muscle using biochemical approaches and genetic screens.